From Fertilization to Organisms

From the 美女直播做爱鈥檚 beginning in 1888, director Charles Otis Whitman inspired cell lineage studies. MBLresearchers studied how a single fertilized egg becomes a multicellular embryo and on to an organized complex organism.

Image of chromosomes, spindle and asters in an egg division HoverTouch to magnify
Nereis egg division
Illustration of an egg division HoverTouch to magnify
Nereis egg division

Using different marine organisms, they followed the lineage through every cell division, watching fertilized egg cells divide into 2, 4, 8 cells, and so on. Fixing, staining, observing, drawing, and photographing allowed each researcher to share and compare with others. The images began to reveal the patterns of development.

Diagram of an egg dividing HoverTouch to magnify
Ascidian egg division

Comparing embryos from different species showed that cells can divide faster or slower, into larger or smaller cells, sometimes through spiral cleavage, and always in ways that cause differentiation among cells that allows them to form organisms.

slipper snail embryos in 1897 and 2014 HoverTouch to magnify
Slipper snail embryo division

Successive cleavage stages in slipper nail embryos from 4 cells (top) to 8 cells (bottom).

Photomicrographs with fluorescently labeled organelles (right).

As they watched the cells divide into many hundreds and even thousands more cells and differentiate, they began to see new cell parts: a nucleus with chromosomes, spindle fibers to help direct the dance of cell division, organelles, and other details.

All this detail led to a larger question: what is common across these cells? What is 鈥渢he cell?鈥