Back to Research Organisms Axolotl Home Groundbreaking Research at the Ůֱ Research Organisms Axolotl Axolotls in the Ůֱ's Echeverri Lab. Credit: Dee Sullivan The Axolotl (Ambystoma mexicanum), also known as the “Mexican salamander,” is a superhero of regeneration. Axolotls can functionally regenerate multiple body parts—including limbs, spinal cord, and parts of the brain and heart—without forming scar tissue. They are native to only one lake (Lake Xochimilco) in Mexico. Axolotls are unusual among amphibians in that they reach adulthood without going through metamorphosis. When the axolotl genome was it was the largest genome ever fully sequenced! (Scientists have since discovered two larger genomes). Axolotls have 32 billion base pairs compared to about 3 billion in humans. Scientific Name: Ambystoma mexicanum Type: AmphibianRange: Lake Xochimilco in MexicoLife Span in the Wild: 10 to 15 yearsSize: Up to 12 inchesWeight: 2.11 to 8 ouncesDiet: Carnivorous: Worms, insect larvae, small crustaceans, fishStatus: Critically endangered in the wild Remote video URL Credit: Marine Biological Laboratory / BioQuest Studios / Nguyen Khoi Nguyen Axolotls and the Ůֱ In the Ůֱ’s Echeverri Lab, scientists studying these animals hope to decipher how the cells of axolotls respond to injury in the spinal cord, limbs, and skin at the cellular and molecular level, and how that process differs from healing in humans, who can’t regenerate. MBLAssociate Scientist Karen Echeverri and her lab are identifying critical molecules, regulatory pathways and cellular processes in the axolotls underlying scar-free regeneration. Learn more about the Echeverri Lab Axolotl News at the Ůֱ Riding the CRISPR Wave February 17, 2023 Take Five: Reflecting on Undergraduate Research at Ůֱ August 24, 2022 Studying a Gene Lurking in the Regeneration Pathway of Axolotls: A Summer of Research at the Ůֱ August 12, 2022 Dr. Karen Echeverri: Regenerate Arms? Spinal Cords? | Critically Speaking Podcast August 3, 2021
Studying a Gene Lurking in the Regeneration Pathway of Axolotls: A Summer of Research at the Ůֱ August 12, 2022