Irina Arkhipova

Senior Scientist

Irina Arkhipova Headshot
Contact Information
Education
BS/MS, Biochemistry, M.V. Lomonosov Moscow State University, 1983
Ph.D., Molecular Biology, Engelhardt Institute of Molecular Biology, Moscow, 1986.
MBLAffiliation
Bay Paul Center
Research Area
Evolution
Genomics

Dr. Irina Arkhipova is a molecular evolutionary geneticist with a background in biochemistry and molecular biology. Her research deals with聽mobile DNA in its broader sense, including different types of transposable elements (TEs) that can move within and between genomes, their genomic impact, genetic and epigenetic regulation, evolutionary origins, and the mechanisms underlying their mobility.听It is often driven by discoveries that were initially made in聽, but which are likely to have broader implications for eukaryotes in general. Her current research is focused on horizontally transferred genes, domesticated reverse transcriptases, and intron-containing retroelements. The overarching goal of her research is to obtain an integrated picture of mobile element structure, function and evolution, encompassing the widest spectrum of their interactions with host genomes, from deleterious to neutral to beneficial. She is a leading expert on transposable elements, which she studied since her undergraduate years, and has authored over 70 publications on this topic. She serves as an expert on national and international advisory panels, as an Associate Editor of聽Molecular Biology and Evolution, and as the Editor-in-Chief of聽Mobile DNA. She is one of the founding members of the聽Mobile Genetic Element Cluster聽at the 美女直播做爱, and since 2007 has been organizing regional, national and international meetings on mobile genetic elements.

News and Research Highlights
Irina Arkhipova works with
no headshot
Senior Researcher
Royal Belgian Institute of Natural Sciences
Selected Publications

Rodriguez F., Yushenova IA, DiCorpo D., and Arkhipova I.R. (2021). Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA.听

Paul, B.G., Yushenova, I.A., and Arkhipova, I.R. (2021). The Diversity of Reverse Transcriptases. In: Retrotransposons; A. Gabriel, ed. World Scientific Publishing: Singapore (in press).

Craig R.J., Yushenova I.A., Rodriguez F., and Arkhipova I.R. (2021). An ancient clade of Penelope-like retroelements with permuted domains is present in early-branching plants and protists, and dominates many invertebrate genomes.听Mol Biol Evol听38(11):5005-5020.听

Nowell R.W., Wilson C.G., Almeida P., Schiffer P.H., Fontaneto D., Becks L., Rodriguez F., Arkhipova I.R., and Barraclough T. (2021). Evolutionary dynamics of transposable elements in bdelloid rotifers.听Elife听10:别63194.听.

Sch枚n I., Rodriguez F., Dunn M., Martens K., Shribak M., and Arkhipova I.R. (2021). A survey of transposon landscapes in the putative ancient asexual ostracod聽Darwinula stevensoni.听Genes聽(Basel), 12(3):401.听

Vakhrusheva O.A., Mnatsakanova E.A., Galimov Y.R., Neretina T.V., Gerasimov E.S., Naumenko S.A., Ozerova S.G., Zalevsky A.O., Yushenova I.A., Rodriguez F., Arkhipova I.R., Penin A.A., Logacheva M.D., Bazykin G.A., and Kondrashov A.S. (2020). Genomic signatures of recombination in a natural population of the bdelloid rotifer聽Adineta vaga.听Nat. Commun.聽11(1):6421.听

Arkhipova I.R. (2020). Metagenome proteins and database contamination.听mSphere聽5:e00854-20.听.

Funikov S.Y., Rezvykh A.P., Kulikova D.A., Zelentsova E.S., Protsenko L.A., Chuvakova L.N., Tyukmaeva V.I., Arkhipova I.R., and Evgen鈥檈v M.B. (2020). Adaptation of gene loci to heterochromatin in the course of Drosophila evolution is associated with insulator proteins.听Sci Rep聽10(1):11893.听

Sharko F.S., Nedoluzhko A.V., L锚 B.M., Tsygankova S.V., Boulygina E.S., Rastorguev S.M., Sokolov A.S., Rodriguez F., Mazur A.M., Polilov A.A., Benton R., Evgen'ev M.B., Arkhipova I.R., Prokhortchouk E.B., and Skryabin K.G. (2019). A partial genome assembly of the miniature parasitoid wasp,聽Megaphragma amalphitanum.听PLoS One, 14(12): e0226485.听

Arkhipova, I.R., and Yushenova, I.A. (2019). Giant transposons in eukaryotes: is bigger better?聽Genome Biol. Evol., 11(3), 906-918.听

Yushenova I.A., and Arkhipova I.R. (2018). Biochemical properties of bacterial reverse transcriptase-related (rvt) gene products: multimerization, protein priming, and nucleotide preference.听Curr. Genet.聽64(6):1287-1301.听

Abrams J.M., Arkhipova I.R., Belfort M., Boeke, J.D., Curcio, M.J., Faulkner, G.J., Goodier, J.L., Lehmann, R., and Levin, H.L. (2018). Meeting report: mobile genetic elements and genome plasticity 2018.听Mob. DNA聽9:21.听

Arkhipova, I.R. (2018). Neutral theory, transposable elements, and eukaryotic genome evolution.听Mol. Biol. Evol.聽35(6): 1332-1337.听

Rodriguez, F., and聽Arkhipova, I.R. (2018). Transposable elements and polyploid evolution in animals.听Curr. Opin. Genet. Dev聽49:115-123.听

Arkhipova I.R., Yushenova I.A., and Rodriguez F. (2017). Giant reverse transcriptase-encoding transposable elements at telomeres.听Mol. Biol. Evol.聽34(9):2245-57.听

Rodriguez F., Kenefick A.W., and Arkhipova I.R. (2017).听LTR retrotransposons from bdelloid rotifers capture additional ORFs shared between highly diverse retroelement types.听Viruses, 9(4): E78.听

Arkhipova, I.R. (2017). Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories.听Mob. DNA聽8:19.听

Arkhipova I.R., Rice P.A. (2016). Mobile Genetic Elements:聽In Silico, In Vitro, In Vivo.听Mol. Ecol. 25(5):1027-31.听.

Rodriguez F., and Arkhipova I.R. (2016). Multitasking of the piRNA silencing machinery: targeting transposable elements and foreign genes in the bdelloid rotifer聽Adineta vaga.听Genetics聽203(1):255-68.听